Levy Brian, Heiler David, Norton Sue
Bausch & Lomb, Rochester, NY, USA.
Eye Contact Lens. 2006 Dec;32(6):256-61. doi: 10.1097/01.icl.0000245556.46738.14.
Recent reports of disproportionate outbreaks of microbial keratitis caused by Fusarium solani have led to the removal of the Bausch & Lomb multipurpose lens care solution ReNu With MoistureLoc ("MoistureLoc") from the global market. Previous studies have shown an increased risk of contact lens-related corneal infection in connection with overnight wear, noncompliant lens wearing and lens care behaviors, specific treatment regimens, and other patient-related and non-patient-related factors. The purpose of the laboratory evaluations reported in this article were to observe the effects of levels of simulated lens care noncompliance on the antimicrobial efficacy of multipurpose solutions following recent reports of F. solani keratitis.
Two multipurpose contact lens care solutions, MoistureLoc and ReNu MultiPlus multipurpose solution ("ReNu MultiPlus"), were tested under conditions that attempted to simulate the possible effect of the noncompliant behaviors reported to Bausch & Lomb as part of the investigation into cases of Fusarium keratitis. Testing conditions included simulated multiple reuse of solutions and evaporation of solutions.
The biocidal efficacy of MoistureLoc and other tested solutions was reduced under conditions that simulated the possible impact of solution reuse. Further investigation of MoistureLoc and ReNu MultiPlus suggests that although efficacy with ReNu MultiPlus was maintained across a variety of noncompliant conditions, the MoistureLoc formula could be rendered less effective under certain conditions.
Under conditions simulating the possible impact of noncompliance, the MoistureLoc solution showed reduced biocidal efficacy. In contrast, ReNu MultiPlus retained a higher level of biocidal activity under the same conditions.
近期有关茄病镰刀菌引起微生物性角膜炎不成比例爆发的报告，导致博士伦多功能隐形眼镜护理液“润明水凝护理液（MoistureLoc）”从全球市场下架。先前的研究表明，与过夜佩戴、不规范的镜片佩戴和护理行为、特定治疗方案以及其他患者相关和非患者相关因素相关的隐形眼镜相关性角膜感染风险增加。本文报告的实验室评估目的是，在近期有茄病镰刀菌角膜炎报告后，观察模拟镜片护理不规范程度对多功能护理液抗菌效果的影响。
两种多功能隐形眼镜护理液，即润明水凝护理液和润明多功能护理液（ReNu MultiPlus），在试图模拟向博士伦报告的不规范行为可能产生的影响的条件下进行了测试，这些不规范行为是镰刀菌角膜炎病例调查的一部分。测试条件包括模拟护理液的多次重复使用和护理液的蒸发。
在模拟护理液重复使用可能产生的影响的条件下，润明水凝护理液和其他测试护理液的杀菌效果降低。对润明水凝护理液和润明多功能护理液的进一步研究表明，尽管润明多功能护理液在各种不规范条件下都能保持疗效，但润明水凝护理液配方在某些条件下可能会失效。
在模拟不规范行为可能产生的影响的条件下，润明水凝护理液的杀菌效果降低。相比之下，润明多功能护理液在相同条件下保持了较高水平的杀菌活性。
