Tales Andrea, Snowden Robert J, Brown Michelle, Wilcock Gordon
Clinical Sciences, Department of Care of the Elderly, University of Bristol, The BRACE Centre, Blackberry Hill Hospital, Bristol, United Kingdom.
Neuropsychology. 2006 Nov;20(6):752-6. doi: 10.1037/0894-4105.20.6.752.
Recently, researchers (E. Festa-Martino, B. R. Ott, & W. C. Heindel, 2004; A. Tales, J. L. Muir, A. Bayer, R. Jones, & R. J. Snowden, 2002; A. Tales, J. L. Muir, A. Bayer, & R. J. Snowden, 2002 have found significantly abnormal spatial orienting together with the abolishment of the alerting effect in Alzheimer's disease (AD). However, these research groups differed in their interpretation of the results. A. Tales, J. L. Muir, A. Bayer, R. Jones, and R. J. Snowden (2002) and A. Tales, J. L. Muir, A. Bayer, and R. J. Snowden (2002) explained their data in terms of two independent processes, whereas E. Festa-Martino et al. (2004) interpreted their findings as indicative of an inverse association, namely that the increased spatial orienting effect in AD was the direct result of the abolition of the phasic alerting effect. In this further study examining exogenous spatial orienting and phasic alerting, the authors present evidence to suggest that the increased spatial orienting effect in AD is not the result of a decreased phasic alerting effect.
最近，研究人员（E. 费斯塔 - 马蒂诺、B. R. 奥特和W. C. 海因德尔，2004年；A. 塔莱斯、J. L. 缪尔、A. 拜尔、R. 琼斯和R. J. 斯诺登，2002年；A. 塔莱斯、J. L. 缪尔、A. 拜尔和R. J. 斯诺登，2002年）发现，阿尔茨海默病（AD）患者存在显著异常的空间定向，同时警觉效应消失。然而，这些研究小组对结果的解释有所不同。A. 塔莱斯、J. L. 缪尔、A. 拜尔、R. 琼斯和R. J. 斯诺登（2002年）以及A. 塔莱斯、J. L. 缪尔、A. 拜尔和R. J. 斯诺登（2002年）用两个独立的过程来解释他们的数据，而E. 费斯塔 - 马蒂诺等人（2004年）则将他们的发现解释为一种反向关联，即AD患者空间定向效应的增加是相位警觉效应消失的直接结果。在这项进一步研究外源性空间定向和相位警觉的研究中，作者提供证据表明，AD患者空间定向效应的增加并非相位警觉效应降低的结果。
