Andoniou Christopher E, Andrews Daniel M, Degli-Esposti Mariapia A
Immunology and Virology Program, Centre for Ophthalmology and Visual Science, the University of Western Australia, Crawley, Western Australia, Australia.
Immunol Rev. 2006 Dec;214:239-50. doi: 10.1111/j.1600-065X.2006.00465.x.
Innate immunity was believed originally to serve simply as the first-line defense against infection and malignancy, with adaptive immunity imposing specificity and ensuring that appropriate responses are mounted against chronic or reoccurring challenges. In this model of immunity, innate and adaptive immune responses are sequential, essentially non-overlapping, and interactions between components of each response limited or non-existent. Over the last 5 years, it has become increasingly evident that interactions between elements of the innate and adaptive immune systems are common. Indeed, it is now clear that the generation and maintenance of effective immunity require an extensive array of interactions between multiple components of the immune system. This review discusses recent advances in this area with particular emphasis on the role of natural killer cells in shaping the adaptive immune response to viral infection.
先天免疫最初被认为仅仅作为针对感染和恶性肿瘤的一线防御，而适应性免疫则赋予特异性并确保针对慢性或反复出现的挑战产生适当的反应。在这种免疫模型中，先天免疫和适应性免疫反应是相继发生的，基本上不重叠，并且每种反应的组成部分之间的相互作用有限或不存在。在过去5年中，越来越明显的是，先天免疫系统和适应性免疫系统的要素之间的相互作用很常见。事实上，现在很清楚，有效免疫的产生和维持需要免疫系统多个组成部分之间广泛的相互作用。本综述讨论了该领域的最新进展，特别强调了自然杀伤细胞在塑造针对病毒感染的适应性免疫反应中的作用。
