Miclard J, Mokhtari K, Jouvion G, Wyrzykowski B, Van Canneyt O, Wyers M, Colle M A
Unité d'Anatomie Pathologique, UMR 703 INRA/ENVN, Ecole Nationale Vétérinaire de Nantes, BP 40706 Nantes Cedex 03, France.
J Comp Pathol. 2006 Nov;135(4):254-8. doi: 10.1016/j.jcpa.2006.08.005.
A wild common dolphin was found stranded on the French Atlantic coast. At necropsy, an intracranial grey- to tan-coloured mass (7 x 5 x 4 cm) was found at the right cerebellopontine angle, compressing the right cerebellar hemisphere, the brainstem and the occipital lobe of the right cerebral hemisphere. Microscopically, the tumour was composed of small lobules of polygonal to elongated neoplastic cells with multifocal areas of stellate and vacuolated cells. Neoplastic cells strongly expressed vimentin, S-100 protein and neuron-specific enolase. They were rarely positive for cytokeratin. Ultrastructurally, the neoplastic cells displayed all the diagnostic features of meningiomas and in some areas showed long cytoplasmic processes delimiting extracellular spaces. The immunohistochemical and ultrastructural features were consistent with the histopathological diagnosis of a microcystic meningioma. This is the first report of a meningioma in dolphins or in any other cetacean species.
一只野生普通海豚被发现搁浅在法国大西洋海岸。尸检时，在右侧小脑脑桥角发现一个颅内灰白色至棕褐色肿块（7×5×4厘米），压迫右侧小脑半球、脑干和右侧大脑半球枕叶。显微镜下，肿瘤由多边形至细长形肿瘤细胞的小叶组成，有星状和空泡状细胞的多灶区域。肿瘤细胞强烈表达波形蛋白、S-100蛋白和神经元特异性烯醇化酶。它们很少呈细胞角蛋白阳性。超微结构上，肿瘤细胞显示出脑膜瘤的所有诊断特征，在某些区域显示出界定细胞外间隙的长细胞质突起。免疫组化和超微结构特征与微囊性脑膜瘤的组织病理学诊断一致。这是关于海豚或任何其他鲸类物种脑膜瘤的首次报道。
