Carlsson P-O, Bodin B, Andersson A, Jansson L
Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden.
Scand J Clin Lab Invest. 2006;66(7):543-8. doi: 10.1080/00365510600861063.
To determine whether carbon monoxide, a known gaseous vasorelaxator, affects pancreatic islet blood flow in rats.
Sprague-Dawley rats were anaesthetized with thiobutabarbital and injected intravenously with the haem oxygenase inhibitor tin-protoporphyrin IX dichloride (SnPP; 4, 10 or 20 mg/kg body-weight). After 15 min, blood flow measurements were performed using a microsphere technique.
There was a slight increase in mean arterial blood pressure with the highest dose of SnPP. No effects on total pancreatic, islet, duodenal, colonic, renal or adrenal blood flow were seen with any of the applied doses.
The findings of this study suggest that the haem oxygenase-carbon monoxide system is likely to be of limited importance in the regulation of blood perfusion to the pancreas, the islets of Langerhans or any of the other studied organs.
确定已知的气态血管舒张剂一氧化碳是否会影响大鼠胰岛的血流。
用硫喷妥巴比妥对斯普拉格-道利大鼠进行麻醉，并静脉注射血红素加氧酶抑制剂二氯化锡原卟啉IX（SnPP；4、10或20毫克/千克体重）。15分钟后，使用微球技术进行血流测量。
最高剂量的SnPP使平均动脉血压略有升高。所应用的任何剂量均未对胰腺、胰岛、十二指肠、结肠、肾脏或肾上腺的总血流产生影响。
本研究结果表明，血红素加氧酶-一氧化碳系统在调节胰腺、胰岛或任何其他研究器官的血液灌注方面可能作用有限。
