Hagio T, Takano Y, Nagashima A, Nakayama Y, Tateishi K, Kamiya H
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan.
Eur J Pharmacol. 1991 Jan 3;192(1):173-6. doi: 10.1016/0014-2999(91)90086-6.
Intracerebroventricular (i.c.v.) injections of a novel tachykinin peptide, gamma-preprotachykinin-(72-92)-peptide amide (neuropeptide gamma, NP gamma), caused dose-dependent increases in blood pressure. The NP gamma-induced pressor responses (1 microgram i.c.v.) were blocked by peripheral administration of pentolinium (10 mg/kg i.v.) and phentolamine (10 mg/kg i.v.), but were not inhibited by a vasopressin antagonist. These results suggest that central NP gamma increases the blood pressure via sympathetic nerve activity.
脑室内注射一种新型速激肽肽，γ-前速激肽-(72-92)-肽酰胺（神经肽γ，NPγ），可引起血压呈剂量依赖性升高。NPγ诱导的升压反应（脑室内注射1微克）可被静脉注射潘托铵（10毫克/千克）和酚妥拉明（10毫克/千克）外周给药阻断，但不受血管加压素拮抗剂抑制。这些结果表明，中枢NPγ通过交感神经活动升高血压。
