Kanadani Fabio N, Dorairaj Syril, Langlieb Alan M, Shihadeh Wisam A, Tello Celso, Liebmann Jeffrey M, Ritch Robert
Department of Ophthalmology, The New York Eye and Ear Infirmary, New York, NY 10003, USA.
Arch Ophthalmol. 2006 Nov;124(11):1573-6. doi: 10.1001/archopht.124.11.1573.
To identify differences in anterior chamber anatomy among patients with asymmetric pigment dispersion syndrome and no other discernible cause for the asymmetry.
Ultrasound biomicroscopy and A-scan biometry were performed on both eyes of 13 patients with asymmetric pigment dispersion syndrome without a known cause for asymmetric involvement. A radial perpendicular image in the horizontal temporal meridian detailing the scleral spur, angle anatomy, and iris configuration was obtained for each eye by 2 examiners.
There were no differences in lens thickness (P = .33), refractive error (P = .84), or axial length (P = .99) between more and less affected eyes. However, the mean +/- SD iris concavity (P<.001), iris-lens contact distance (P = .02), and distance from the scleral spur to the iris insertion (0.42 +/- 0.11 vs 0.29 +/- 0.06 mm) (P = .002) were greater in the more affected eye of each patient.
A more posterior iris insertion predisposes to the phenotypic expression of pigment dispersion syndrome.
确定不对称性色素播散综合征且无其他可识别的不对称病因患者的前房解剖结构差异。
对13例无已知不对称受累病因的不对称性色素播散综合征患者的双眼进行超声生物显微镜检查和A超生物测量。两名检查者为每只眼睛获取了水平颞侧子午线的径向垂直图像，详细显示了巩膜突、房角解剖结构和虹膜形态。
受累程度较重和较轻的眼睛在晶状体厚度（P = 0.33）、屈光不正（P = 0.84）或眼轴长度（P = 0.99）方面无差异。然而，每位患者受累较重眼睛的平均±标准差虹膜凹陷度（P<0.001）、虹膜-晶状体接触距离（P = 0.02）以及从巩膜突到虹膜附着点的距离（0.42±0.11 vs 0.29±0.06 mm）（P = 0.002）更大。
虹膜附着点更靠后易引发色素播散综合征的表型表达。
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