转移性类癌瘤所致异位库欣综合征的姑息治疗。

Palliative therapy of an ectopic Cushing's syndrome due to a metastatic carcinoid tumor.

作者信息

Kornely E, Schlaghecke R, Horster F A

机构信息

Medizinische Klinik und Poliklinik, Abteilung für Endokrinologie und Rheumatologie, Heinrich Heine Universität Düsseldorf, FRG.

出版信息

Klin Wochenschr. 1991 Feb 26;69(4):173-6. doi: 10.1007/BF01665863.

DOI:10.1007/BF01665863

PMID:1710306

Abstract

The case of a 39-year-old patient with ectopic Cushing's syndrome due to a metastatic carcinoid tumor is presented. Palliative therapy consisting of 800 mg ketoconazole and 0.3 mg SMS 201-995/die resulted in clinical remission and correction of hypokalemia and hypercortisoluria. Combined therapy was clearly superior to monotherapy with ketoconazole or SMS 201-995, respectively. Side effects were not observed, the tumor masses remained unchanged throughout the observation period of now 19 months.

摘要

本文报告了一例39岁因转移性类癌肿瘤导致异位库欣综合征的患者。采用每日800毫克酮康唑和0.3毫克SMS 201-995的姑息治疗导致临床缓解以及低钾血症和高皮质醇尿症的纠正。联合治疗明显优于分别使用酮康唑或SMS 201-995的单一疗法。未观察到副作用，在目前19个月的观察期内肿瘤肿块保持不变。