编码人非选择性内皮素受体的cDNA的克隆与序列分析
Cloning and sequence analysis of a cDNA encoding human non-selective type of endothelin receptor.
作者信息
Nakamuta M, Takayanagi R, Sakai Y, Sakamoto S, Hagiwara H, Mizuno T, Saito Y, Hirose S, Yamamoto M, Nawata H
机构信息
Third Department of Internal Medicine, Faculty of Medicine, Kyushu University, Japan.
出版信息
Biochem Biophys Res Commun. 1991 May 31;177(1):34-9. doi: 10.1016/0006-291x(91)91944-8.
A cDNA encoding non-selective type (ETB) of endothelin receptor was isolated from a human liver cDNA library. The cDNA had an open reading frame encoding a protein of 442 amino acid residues with a relative Mr of 49,643. The deduced amino acid sequence of human ETB receptor was 88% and 64% identical to those of rat lung ETB receptor and bovine lung ET-1-specific (ETA) receptor, respectively, and contained a relatively long and proline-rich extracellular N-terminal region in addition to a significant similarity with the G protein-coupled receptor super-family with seven transmembrane segments.
从人肝脏cDNA文库中分离出一种编码内皮素受体非选择性类型（ETB）的cDNA。该cDNA具有一个开放阅读框，编码一个由442个氨基酸残基组成的蛋白质，相对分子质量为49,643。推导的人ETB受体氨基酸序列与大鼠肺ETB受体和牛肺ET-1特异性（ETA）受体的氨基酸序列分别具有88%和64%的同一性，除了与具有七个跨膜区段的G蛋白偶联受体超家族有显著相似性外，还包含一个相对较长且富含脯氨酸的细胞外N端区域。
Zotero 插件