González-Pérez Ma I
Servicio de Medicina Intensiva, Complejo Hospitalario de León, León.
Neurocirugia (Astur). 2006 Oct;17(5):433-9.
This study was designed to evaluate patients with confirmed aneurismal SAH (subarachnoid haemorrhage) in Leo n Hospital between 2001 and 2003.
The treatment protocol includes: rapid transfer to the reference centre, blood pressure control and nimodipine infusion, arteriography and endovascular treatment within the first 72 hours after admission. Surgery is performed as soon as possible if embolization is not possible. Aggressive antiaeschemic handling and transcranial Doppler are used for diagnosis and vasospasm monitoring. The patients were classified on admission according to the Hunt-Hess scale. Monitoring continued until discharge, and morbidity (any degree of neurological deficiency on discharge, not paralysis of a cranial pair) and mortality were analysed. P< 0.05 was considered statistically significant.
During the study period 54 patients had SAH on admission, 86% of whom were admitted to Intensive Care Unit 24 hours after bleeding. Five patients were not treated as they had massive SAH with Hunt-Hess V. Four of them died . Of the remaining 49 patients (90.74%) embolization was successful in 28 (54% ) but 21 (38%) were not embolized due to the characteristics of the aneurysm; they were operated on within the following 72 hours. Six embolized 16.8%) and 3 (14.2%) patients operated on had neurological sequelae (p> 0.05). Three endovascularly treated patients (14.2%) and 4 (19%) surgically treated died (p>0.05 ). The frequency of clinical vasospasm was 20% an rebleeding occurred in 16%. The length of stay in the ICU of embolized patients was significantly shorter than the operated patients (6.1 vs 8.8 )days, p<0.05.
The endovascular treatment can be successfully carried out in over half of the patients with ruptured aneurysms. There is a significant relationship between the degree of consciousness on admission and the prognosis. We found no statistically significant differences in morbid-mortality between the embolized patients and those undergoing conventional surgery. However, there was a difference in length of stay in the ICU (shorter in patients treated by endovascular coiling).
本研究旨在评估2001年至2003年期间在莱昂医院确诊为动脉瘤性蛛网膜下腔出血(SAH)的患者。
治疗方案包括:迅速转至参考中心、控制血压和输注尼莫地平、在入院后72小时内进行血管造影和血管内治疗。若无法进行栓塞,则尽快进行手术。采用积极的抗缺血处理和经颅多普勒进行诊断和血管痉挛监测。患者入院时根据Hunt-Hess量表进行分类。监测持续至出院,并分析发病率(出院时任何程度的神经功能缺损,而非颅神经麻痹)和死亡率。P<0.05被认为具有统计学意义。
在研究期间,54例患者入院时患有SAH,其中86%在出血后24小时内入住重症监护病房。5例患者因患有大量SAH且Hunt-Hess分级为V级而未接受治疗,其中4例死亡。其余49例患者(90.74%)中,28例(54%)栓塞成功,但21例(38%)因动脉瘤的特征未进行栓塞;他们在接下来的72小时内接受了手术。6例(16.8%)接受栓塞治疗和3例(14.2%)接受手术治疗的患者有神经后遗症(P>0.05)。3例(14.2%)接受血管内治疗的患者和4例(19%)接受手术治疗的患者死亡(P>0.05)。临床血管痉挛的发生率为20%,再出血发生率为16%。接受栓塞治疗的患者在重症监护病房的住院时间明显短于接受手术治疗的患者(6.1天对8.8天),P<0.05。
超过半数的破裂动脉瘤患者可成功进行血管内治疗。入院时的意识程度与预后之间存在显著关系。我们发现栓塞治疗患者与接受传统手术患者的病死情况无统计学显著差异。然而,在重症监护病房的住院时间存在差异(血管内栓塞治疗患者较短)。