手性二氨基二膦-铱（I）配合物催化外消旋仲醇的动力学拆分

Kinetic resolution of racemic secondary alcohols catalyzed by chiral diaminodiphosphine-Ir(I) complexes.

作者信息

Li Yan-Yun, Zhang Xue-Qin, Dong Zhen-Rong, Shen Wei-Yi, Chen Gui, Gao Jing-Xing

机构信息

State Key Laboratory of Physical Chemistry of Solid Surfaces and Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, Fujian, Peoples Republic of China.

出版信息

Org Lett. 2006 Nov 23;8(24):5565-7. doi: 10.1021/ol062244f.

DOI:10.1021/ol062244f

PMID:17107073

Abstract

Chiral diaminodiphosphine-Ir(I) complexes were found to efficiently catalyze enantioselective oxidation of racemic secondary alcohols in acetone. In the presence of base, oxidative kinetic resolution of the alcohols proceeded smoothly with excellent enantioselectivity (up to 98% ee) under mild conditions. [reaction: see text].

摘要

发现手性二氨基二膦-Ir(I)配合物能有效地催化外消旋仲醇在丙酮中的对映选择性氧化反应。在碱存在的情况下，醇的氧化动力学拆分在温和条件下顺利进行，对映选择性优异（高达98% ee）。[反应：见正文]