Falagas Matthew E, Koletsi Patra K, Bliziotis Ioannis A
Department of Medicine, Tufts University School of Medicine, Boston, Massachusetts, USA.
Alfa Institute of Biomedical Sciences (AIBS), 9 Neapoleos Street, 151 23 Marousi, Athens, Greece.
J Med Microbiol. 2006 Dec;55(Pt 12):1619-1629. doi: 10.1099/jmm.0.46747-0.
Different definitions of the terms multidrug-resistant (MDR) and pandrug-resistant (PDR) Acinetobacter baumannii and Pseudomonas aeruginosa have been used in the biomedical literature. The authors searched for relevant studies indexed in the PubMed database (01/2000-09/2005) to systematically examine the various definitions of MDR and PDR for these bacteria. Initially 107 retrieved relevant studies were reviewed. Ninety-two studies were further analysed, 50 of which focused on A. baumannii and 42 on P. aeruginosa. A considerable diversity of definitions of the terms MDR and PDR A. baumannii and P. aeruginosa was found. Of note, the term PDR was inappropriately used in all five studies that used it. The review reveals that various definitions have been used for the terms MDR and PDR A. baumannii and P. aeruginosa, a fact that causes confusion to researchers and clinicians. The authors believe that at least a widely accepted definition for PDR A. baumannii and P. aeruginosa should be uniformly used worldwide.
生物医学文献中对多重耐药（MDR）鲍曼不动杆菌和泛耐药（PDR）鲍曼不动杆菌以及多重耐药铜绿假单胞菌和泛耐药铜绿假单胞菌使用了不同的定义。作者检索了PubMed数据库（2000年1月 - 2005年9月）中索引的相关研究，以系统地审查这些细菌的MDR和PDR的各种定义。最初对检索到的107项相关研究进行了审查。进一步分析了92项研究，其中50项聚焦于鲍曼不动杆菌，42项聚焦于铜绿假单胞菌。发现多重耐药鲍曼不动杆菌和泛耐药鲍曼不动杆菌以及多重耐药铜绿假单胞菌和泛耐药铜绿假单胞菌这些术语的定义存在相当大的差异。值得注意的是，在使用“泛耐药”一词的所有五项研究中，该词的使用都是不恰当的。该综述表明，多重耐药鲍曼不动杆菌和泛耐药鲍曼不动杆菌以及多重耐药铜绿假单胞菌和泛耐药铜绿假单胞菌这些术语使用了各种不同的定义，这一事实给研究人员和临床医生造成了困惑。作者认为，至少对于泛耐药鲍曼不动杆菌和泛耐药铜绿假单胞菌，应该在全球统一使用一个被广泛接受的定义。
