Frampton Mark W
Division of Pulmonary and Critical Care Medicine, University of Rochester Medical Center, Rochester, NY 14642-8692, USA.
Clin Occup Environ Med. 2006;5(4):797-815. doi: 10.1016/j.coem.2006.07.006.
Inflammation provides a potential mechanistic link between inhalation of particles and the diverse health effects found in epidemiologic studies. Considerable uncertainty remains as to the importance of the inflammation in mediating these effects and where that inflammation is occurring: lung, vascular endothelium, or distant organs, including the heart. This article briefly reviews the role of inflammation in pulmonary and cardiovascular disease and explores the evidence that the health effects of PM exposure are mediated, at least in part, by inflammation.
炎症为吸入颗粒物与流行病学研究中发现的多种健康影响之间提供了潜在的机制联系。关于炎症在介导这些影响中的重要性以及炎症发生的部位（肺、血管内皮或包括心脏在内的远处器官）仍存在相当大的不确定性。本文简要回顾了炎症在肺部和心血管疾病中的作用，并探讨了有证据表明暴露于细颗粒物对健康的影响至少部分是由炎症介导的。
