胸腺移植。对一名患有T细胞缺陷的四岁患者的细胞免疫进行重建。
Thymus transplantation. Reconstitution of cellular immunity in a four-year-old patient with T-cell deficiency.
作者信息
Businco L, Rezza E, Giunchi G, Aiuti F
出版信息
Clin Exp Immunol. 1975 Jul;21(1):32-38.
Abstract
The case is reported of a 4-year-old girl affected with recurrent infections; anaemia, thrombocytopenia, haemorrhages and hepatosplenomegaly. Immunological investigations revealed a defect in cellular immunity related to the thymus-dependent system, hypergammaglobulinaemia (especially of class IgE), and very high titres of antibodies against Epstein-Barr virus (EBV). After foetal thymus transplantation, correction of the immunological defect and significant clinical improvement were noted, as well as a decrease of IgE and EBV antibody titres.
摘要
报告了一例4岁女童，患有反复感染、贫血、血小板减少、出血和肝脾肿大。免疫学检查发现与胸腺依赖系统相关的细胞免疫缺陷、高丙种球蛋白血症（尤其是IgE类）以及针对爱泼斯坦-巴尔病毒（EBV）的抗体滴度非常高。胎儿胸腺移植后，免疫缺陷得到纠正，临床有显著改善，同时IgE和EBV抗体滴度降低。
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1
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Int Arch Allergy Appl Immunol. 1965;27:6-26. doi: 10.1159/000229594.
2
[LESIONS SUGGESTING AN AUTOIMMUNE REACTIVITY IN MICE WITH "RUNT DISEASE" AFTER NEONATAL THYMECTOMY].[新生期胸腺切除后出现“侏儒病”的小鼠中提示自身免疫反应性的病变]
Rev Fr Etud Clin Biol. 1964 Apr;9:381-97.
3
[Lymphocytophthisis with dysgammaglobulinemia in an infant].
Arch Fr Pediatr. 1963 Feb;20:131-46.
4
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5
[A case of chronic neutropenia and autoimmune hemolytic anemia in child 2 years and 7 months old].
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6
Detection of tuberculin sensitivity in children by leukocyte culture.
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7
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8
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