孕期接触甲苯对大鼠自发活动及苯丙胺诱导的运动行为的影响。
Gestational toluene exposure effects on spontaneous and amphetamine-induced locomotor behavior in rats.
作者信息
Bowen Scott E, Mohammadi Michael H, Batis Jeffery C, Hannigan John H
机构信息
Department of Psychology, Wayne State University, Detroit, MI 48202, USA.
出版信息
Neurotoxicol Teratol. 2007 Mar-Apr;29(2):236-46. doi: 10.1016/j.ntt.2006.09.027. Epub 2006 Oct 6.
Gestational Toluene Exposure Effects on Spontaneous and Amphetamine-Induced Locomotor Behavior in Rats. Bowen, S.E., Mohammadi, M.H., Batis, J.C., and Hannigan, J.H. Neurotoxicology and Teratology, XX, 2006. The abuse of volatile organic solvents (inhalants) continues to be a major health concern throughout the world. Toluene, which is found in many products such as glues and household cleaners, is among the most commonly abused organic solvents. The neurobehavioral teratogenic sequelae of solvent abuse (i.e., repeated, brief inhalation exposures to very high concentrations of solvents) have not been examined thoroughly. In a preclinical model of inhalant abuse, timed-pregnant Sprague-Dawley rats were exposed to 0, 8000, or 12,000 parts per million (ppm) for 15 min twice daily from gestation day 8 (GD8) through GD20. In the first experiment, separate groups of offspring were observed individually in an open-field on postnatal day 22 (PN22), PN42 or PN63. In the second experiment, other offspring given identical prenatal toluene exposures were observed in an "open-field" following an acute i.p. injection of amphetamine (0, 0.56, 1.78 mg/kg) on PN28. Automated measurements of distance traveled and ambulatory time were recorded. Prenatal toluene exposure resulted in small alterations in spontaneous activity compared to non-exposed rats. Prenatal exposure to 12,000 ppm toluene resulted in significant hyposensitivity to the locomotor stimulatory effects of the amphetamine challenge in male but not female rats on PN28. The results demonstrate that prenatal exposure to abuse patterns of high concentrations of toluene through inhalation can alter spontaneous and amphetamine-induced locomotor behavior in rats. The expression of these effects also appears to depend upon the postnatal age of testing. These results imply that abuse of organic solvents during pregnancy in humans may also produce long-lasting effects on biobehavioral development.
孕期接触甲苯对大鼠自发及苯丙胺诱导的运动行为的影响。鲍恩，S.E.，穆罕默迪，M.H.，巴蒂斯，J.C.，以及汉尼根，J.H.《神经毒理学与致畸学》，XX，2006年。挥发性有机溶剂（吸入剂）的滥用仍是全球主要的健康问题。甲苯存在于许多产品中，如胶水和家用清洁剂，是最常被滥用的有机溶剂之一。溶剂滥用（即反复、短暂吸入极高浓度的溶剂）的神经行为致畸后遗症尚未得到充分研究。在一个吸入剂滥用的临床前模型中，从妊娠第8天（GD8）至GD20，将定时怀孕的斯普拉格-道利大鼠每天两次暴露于0、8000或12000 ppm的甲苯中，每次暴露15分钟。在第一个实验中，在出生后第22天（PN22）、PN42或PN63，分别对不同组的后代在旷场中进行单独观察。在第二个实验中，在出生后第28天（PN28）对其他接受相同产前甲苯暴露的后代进行急性腹腔注射苯丙胺（0、0.56、1.78 mg/kg）后，在“旷场”中进行观察。记录行进距离和移动时间的自动测量结果。与未暴露的大鼠相比，产前接触甲苯导致自发活动出现微小变化。产前暴露于12000 ppm甲苯导致雄性大鼠在PN28时对苯丙胺激发的运动刺激效应显著低敏，而雌性大鼠则未出现这种情况。结果表明，孕期通过吸入接触高浓度甲苯的滥用模式可改变大鼠的自发及苯丙胺诱导的运动行为。这些效应的表现似乎还取决于测试的产后年龄。这些结果意味着，人类孕期滥用有机溶剂也可能对生物行为发育产生持久影响。
Zotero 插件