Saijo Ryosuke, Tsunekawa Saori, Murakami Hiroyuki, Shirai Naohiro, Ikeda Shin-ichi, Odashima Kazunori
Graduate School of Pharmaceutical Sciences, Nagoya City University, Mizuho-ku, Nagoya 467-8603, Japan.
Bioorg Med Chem Lett. 2007 Feb 1;17(3):767-71. doi: 10.1016/j.bmcl.2006.10.073. Epub 2006 Oct 28.
New ditopic sensory elements 2 and 3 for catecholamines based on a hexahomotrioxacalix[3]arene, with a boronic acid substituent appended, were designed and synthesized. As an interesting mode of molecular recognition at membrane surfaces, the host, when incorporated into poly(vinyl chloride) (PVC) liquid membranes, displayed excellent potentiometric selectivity for dopamine over other catecholamines (noradrenaline and adrenaline) and inorganic cations (Na+, K+, and NH4+).
设计并合成了基于六聚同系三氧杂杯[3]芳烃并带有硼酸取代基的新型双位点儿茶酚胺传感元件2和3。作为膜表面一种有趣的分子识别模式，该主体在被掺入聚氯乙烯（PVC）液膜中时，对多巴胺表现出优于其他儿茶酚胺（去甲肾上腺素和肾上腺素）及无机阳离子（Na⁺、K⁺和NH₄⁺）的优异电位选择性。
