[Monoclonal antibodies against determinants on human MHC class II antigens]. - Suppr | 超能文献

[Monoclonal antibodies against determinants on human MHC class II antigens].

作者信息

Eichler W, Seifert M, Fiebig H

机构信息

Bereich Tierphysiologie und Immunbiologie, Karl-Marx-Universität Leipzig.

出版信息

Allerg Immunol (Leipz). 1990;36(4):309-20.

Abstract

Monoclonal antibodies against different non-polymorphic determinants of HLA class II antigens are described. The epitopes are present on HLA-DR and HLA-DQ gene products as detected by monoclonal antibody BL-Ia/l, and at HLA-DR and HLA-DP gene products which are recognized by monoclonal antibody BL-Ia/4. Another epitope recognized by the monoclonal antibody BL-Ia/DQ is only found on DQ molecules. The monoclonal antibodies BL-Ia/1, BL-Ia/4, and BL-Ia/5 are directed against the beta-subunit of 29 kDa/35 kDa class II heterodimer molecules. The recognized epitopes are shown to be not dependent on the association of the alpha- and beta-chains.

摘要

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