Kaida K, Morita D, Kanzaki M, Kamakura K, Motoyoshi K, Hirakawa M, Kusunoki S
Third Department of Internal Medicine, National Defense Medical College, 3-2 Namiki, Saitama-ken, 359-8513, Japan.
J Neuroimmunol. 2007 Jan;182(1-2):212-8. doi: 10.1016/j.jneuroim.2006.09.013. Epub 2006 Nov 16.
Ganglioside complexes (GSCs) are known as target antigens in Guillain-Barré syndrome (GBS). To elucidate the clinical importance of the anti-GSC antibodies in GBS, we investigated serum antibodies to GSCs containing two of the gangliosides, GM1, GD1a, GD1b and GT1b, and analyzed clinical features of anti-GSC-positive GBS patients. Thirty-nine (17%) of 234 GBS patients had IgG anti-GSC antibodies. Anti-GSC-positive GBS had antecedent gastrointestinal infection and lower cranial nerve deficits more frequently than control GBS. The presence of antibody specificity to GD1a/GD1b and/or GD1b/GT1b was significantly associated with severe disability and a requirement for mechanical ventilation.
神经节苷脂复合物（GSCs）被认为是吉兰 - 巴雷综合征（GBS）中的靶抗原。为阐明抗GSC抗体在GBS中的临床重要性，我们研究了针对包含神经节苷脂GM1、GD1a、GD1b和GT1b中两种的GSCs的血清抗体，并分析了抗GSC阳性GBS患者的临床特征。234例GBS患者中有39例（17%）具有IgG抗GSC抗体。抗GSC阳性GBS比对照GBS更频繁地出现前驱胃肠道感染和下颅神经缺损。对GD1a/GD1b和/或GD1b/GT1b的抗体特异性的存在与严重残疾和机械通气需求显著相关。
