B族维生素可降低β淀粉样蛋白的血浆水平。

B-vitamins reduce plasma levels of beta amyloid.

作者信息

Flicker Leon, Martins Ralph N, Thomas Jenny, Acres John, Taddei Kevin, Vasikaran Samuel D, Norman Paul, Jamrozik Konrad, Almeida Osvaldo P

机构信息

School of Medicine and Pharmacology, University of Western Australia, Australia.

出版信息

Neurobiol Aging. 2008 Feb;29(2):303-5. doi: 10.1016/j.neurobiolaging.2006.10.007. Epub 2006 Nov 20.

DOI:10.1016/j.neurobiolaging.2006.10.007

PMID:17113685

Abstract

Elevated plasma homocysteine (tHcy) is a risk factor for Alzheimer's disease (AD), and thus B vitamins may have a role in the prevention of AD. The objective of this study was to determine if tHcy lowering vitamins decrease the circulating levels of A-beta protein 1-40 (A beta 40). We randomized 299 older men to treatment with 2mg of folate, plus 25mg of B6 and 400 microg of B12, or placebo. After 2 years of treatment the mean (S.E.) increase of A beta 40 was 7.0 pg/ml (8.4) in the vitamin group (4.9%), and 26.8 pg/ml (7.7) (18.5%) in the placebo group. We conclude that B vitamins may decrease the plasma level of A beta 40 and have a role in the prevention of AD.

摘要

血浆同型半胱氨酸（总同型半胱氨酸）水平升高是阿尔茨海默病（AD）的一个风险因素，因此B族维生素可能在预防AD中发挥作用。本研究的目的是确定降低总同型半胱氨酸的维生素是否会降低β淀粉样蛋白1-40（Aβ40）的循环水平。我们将299名老年男性随机分为两组，一组接受2毫克叶酸、25毫克维生素B6和400微克维生素B12治疗，另一组接受安慰剂治疗。治疗2年后，维生素组Aβ40的平均（标准误）增加量为7.0皮克/毫升（8.4）（4.9%），安慰剂组为26.8皮克/毫升（7.7）（18.5%）。我们得出结论，B族维生素可能会降低Aβ40的血浆水平，并在预防AD中发挥作用。