Hassan C, Zullo A, Winn S, Eramo A, Tomao S, Rossini F P, Morini S
Gastroenterology and Digestive Endoscopy Unit, Nuovo Regina Margherita Hospital, Rome, Italy.
Dig Liver Dis. 2007 Jan;39(1):92-100. doi: 10.1016/j.dld.2006.06.039. Epub 2006 Nov 20.
Colorectal adenomas containing invasive carcinoma represent the majority of early colorectal cancers. The malignant polyp carries a significant risk of lympho-haematic metastasis and mortality due to the penetration of cancerous cells into the submucosal layer. The therapeutic dilemma is whether to perform endoscopic or surgical resection. A thorough assessment of the endoscopic, histological and clinical variables is needed to unravel the best treatment for each patient. In particular, a unique staging of such lesions, based on certain histopathological features, has been deeply implicated in the therapeutic choice. Aim of this article is to review the main endoscopic, histological and clinical features of the malignant polyp in order to propose a systematic management of this lesion.
含有浸润性癌的大肠腺瘤占早期大肠癌的大多数。恶性息肉因癌细胞穿透至黏膜下层而具有显著的淋巴血行转移风险及致死风险。治疗上的两难之处在于选择内镜切除还是手术切除。需要对内镜、组织学及临床变量进行全面评估,以确定针对每位患者的最佳治疗方案。特别是,基于某些组织病理学特征对此类病变进行独特的分期,对治疗选择有着深远影响。本文旨在综述恶性息肉的主要内镜、组织学及临床特征,以便对此类病变提出系统的管理方案。