McMurray John S
Department of Experimental Therapeutics, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 36, Houston, Texas 77030, USA.
Chem Biol. 2006 Nov;13(11):1123-4. doi: 10.1016/j.chembiol.2006.11.001.
In this issue of Chemistry & Biology, Schust et al. report the discovery of a small molecule (Stattic) that inhibits the binding of a high affinity phosphopeptide for the SH2 domain of Stat3. Stattic is a new tool for studying Stat3 signaling and demonstrates that the SH2 domain is not a dead target.
在本期《化学生物学》中，舒斯特等人报道了一种小分子（Stattic）的发现，该小分子可抑制Stat3的SH2结构域与高亲和力磷酸肽的结合。Stattic是研究Stat3信号传导的一种新工具，并表明SH2结构域并非是一个无活性的靶点。
