Gamian A, Chomik M, Laferrière C A, Roy R
Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw.
Can J Microbiol. 1991 Mar;37(3):233-7. doi: 10.1139/m91-035.
Multivalent forms of neoglycoproteins and polyacrylamides containing sialic acid were prepared and shown to be potent inhibitors of influenza A virus (H3N2) hemagglutinin with chick red blood cells. The synthetic sialylated glycoconjugates, although they were neuraminidase substrates, did not suppress viral neuraminidase and did not reduce infectivities in chick embryos. The copolyacrylamide conjugate containing a spacer group of approximately 11 A (1 A = 0.1 nm) between the polymer backbone and the sialic acid residues was the best hemagglutinin inhibitor. Moreover, it exhibited promising interferon-inducing properties.
制备了含有唾液酸的新糖蛋白和聚丙烯酰胺的多价形式，并证明它们是甲型流感病毒（H3N2）血凝素对鸡红细胞的有效抑制剂。合成的唾液酸化糖缀合物虽然是神经氨酸酶的底物，但不抑制病毒神经氨酸酶，也不降低鸡胚中的感染性。在聚合物主链和唾液酸残基之间含有约11埃（1埃=0.1纳米）间隔基团的共聚聚丙烯酰胺缀合物是最好的血凝素抑制剂。此外，它还表现出有前景的干扰素诱导特性。
