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Severe acute toxicity associated with high-dose methotrexate (MTX) therapy: use of therapeutic drug monitoring and test-dose to guide carboxypeptidase G2 rescue and MTX continuation.

作者信息

Estève M-A, Devictor-Pierre B, Galy G, André N, Coze C, Lacarelle B, Bernard J-L, Monjanel-Mouterde S

机构信息

Laboratoire de Pharmacocinétique et de Toxicocinétique, CHU Timone, 254 rue St Pierre, 13005 Marseille, France.

出版信息

Eur J Clin Pharmacol. 2007 Jan;63(1):39-42. doi: 10.1007/s00228-006-0212-1. Epub 2006 Nov 18.

DOI:10.1007/s00228-006-0212-1
PMID:17115148
Abstract
摘要

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Severe acute toxicity associated with high-dose methotrexate (MTX) therapy: use of therapeutic drug monitoring and test-dose to guide carboxypeptidase G2 rescue and MTX continuation.与高剂量甲氨蝶呤（MTX）治疗相关的严重急性毒性：使用治疗药物监测和试验剂量指导羧肽酶G2解救及MTX继续治疗。
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2
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本文引用的文献

1
Carboxypeptidase G2 rescue in patients with methotrexate intoxication and renal failure.羧肽酶G2对甲氨蝶呤中毒合并肾衰竭患者的救治作用
Br J Cancer. 2005 Feb 14;92(3):480-7. doi: 10.1038/sj.bjc.6602337.
2
High-dose methotrexate-induced nephrotoxicity in patients with osteosarcoma.高剂量甲氨蝶呤诱发骨肉瘤患者的肾毒性。
Cancer. 2004 May 15;100(10):2222-32. doi: 10.1002/cncr.20255.
3
Optimal management of methotrexate intoxication in a child with osteosarcoma.骨肉瘤患儿甲氨蝶呤中毒的最佳管理
ERG可诱导去势抵抗性前列腺癌产生紫杉烷耐药性。
Nat Commun. 2014 Nov 25;5:5548. doi: 10.1038/ncomms6548.
4
Glucarpidase to combat toxic levels of methotrexate in patients.用葡醛内酯治疗甲氨蝶呤中毒的患者。
Ther Clin Risk Manag. 2012;8:403-13. doi: 10.2147/TCRM.S30135. Epub 2012 Nov 22.
5
Resumption of high-dose methotrexate after acute kidney injury and glucarpidase use in pediatric oncology patients.儿童肿瘤患者在急性肾损伤后使用甲氨蝶呤和葡萄糖醛酸酶后恢复使用大剂量甲氨蝶呤。
Cancer. 2012 Sep 1;118(17):4321-30. doi: 10.1002/cncr.27378. Epub 2012 Jan 17.
6
Glucarpidase, leucovorin, and thymidine for high-dose methotrexate-induced renal dysfunction: clinical and pharmacologic factors affecting outcome.甲氨蝶呤致肾功能障碍时用葡醛内酯、亚叶酸钙和胸苷解救：影响疗效的临床和药理学因素。
J Clin Oncol. 2010 Sep 1;28(25):3979-86. doi: 10.1200/JCO.2009.25.4540. Epub 2010 Aug 2.
Ann Pharmacother. 2004 Mar;38(3):422-7. doi: 10.1345/aph.1D237. Epub 2004 Jan 23.
4
Influence of high-dose methotrexate therapy (HD-MTX) on glomerular and tubular kidney function.大剂量甲氨蝶呤疗法（HD-MTX）对肾小球和肾小管肾功能的影响。
Med Pediatr Oncol. 2003 Jun;40(6):348-54. doi: 10.1002/mpo.10293.
5
Carboxypeptidase-G2 rescue in cancer patients with delayed methotrexate elimination after high-dose methotrexate therapy.羧肽酶G2对大剂量甲氨蝶呤治疗后甲氨蝶呤清除延迟的癌症患者的挽救作用。
Leuk Lymphoma. 2002 Nov;43(11):2139-43. doi: 10.1080/1042819021000032953.
6
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J Pharmacol Exp Ther. 2000 Sep;294(3):894-901.
7
Benefits of pharmacological knowledge in the design and monitoring of cancer chemotherapy.药理学知识在癌症化疗设计与监测中的益处。
Pathol Oncol Res. 1998;4(3):171-8. doi: 10.1007/BF02905246.
8
Carboxypeptidase-G2, thymidine, and leucovorin rescue in cancer patients with methotrexate-induced renal dysfunction.羧肽酶-G2、胸腺嘧啶核苷和亚叶酸钙对甲氨蝶呤诱导的肾功能不全癌症患者的解救作用。
J Clin Oncol. 1997 May;15(5):2125-34. doi: 10.1200/JCO.1997.15.5.2125.
9
Carboxypeptidase-G2 rescue in a patient with high dose methotrexate-induced nephrotoxicity.羧肽酶G2对一名高剂量甲氨蝶呤诱导的肾毒性患者的救治作用
Cancer. 1995 Aug 1;76(3):521-6. doi: 10.1002/1097-0142(19950801)76:3<521::aid-cncr2820760325>3.0.co;2-m.
10
Pharmacokinetics of high-dose methotrexate in adult osteogenic sarcoma.大剂量甲氨蝶呤在成人骨肉瘤中的药代动力学
Cancer Chemother Pharmacol. 1994;33(5):420-4. doi: 10.1007/BF00686272.