Kamermans M, van Dijk B W, Spekreijse H
Laboratory of Medical Physics, University of Amsterdam, The Netherlands.
J Gen Physiol. 1991 Apr;97(4):819-43. doi: 10.1085/jgp.97.4.819.
The spectral and dynamic properties of cone-driven horizontal cells in carp retina were evaluated with silent substitution stimuli and/or saturating background illumination. The aim of this study was to describe the wiring underlying the spectral sensitivity of these cells. We will present electrophysiological data that indicate that all cone-driven horizontal cell types receive input from all spectral cone types, and we will present evidence that all cone-driven horizontal cell types feedback to all spectral cone types. These two findings are the basis for a model for the spectral and dynamic behavior of all cone-driven horizontal cells in carp retina. The model can account for the spectral as well as the dynamic behavior of the horizontal cells. It will be shown that the strength of the feedforward and feedback pathways between a horizontal cell and a particular spectral cone type are roughly proportional. This model is in sharp contrast to the Stell model, where the spectral behavior of the three horizontal cell types is explained by a cascade of feedforward and feedback pathways between cones and horizontal cells. The Stell model accounts for the spectral but not for the dynamic behavior of the horizontal cells.
利用无信号替代刺激和/或饱和背景照明评估了鲤鱼视网膜中视锥细胞驱动的水平细胞的光谱和动态特性。本研究的目的是描述这些细胞光谱敏感性背后的神经连接。我们将展示电生理数据，这些数据表明所有视锥细胞驱动的水平细胞类型都接收来自所有光谱视锥细胞类型的输入，并且我们将提供证据表明所有视锥细胞驱动的水平细胞类型都反馈到所有光谱视锥细胞类型。这两个发现是鲤鱼视网膜中所有视锥细胞驱动的水平细胞光谱和动态行为模型的基础。该模型可以解释水平细胞的光谱和动态行为。将表明水平细胞与特定光谱视锥细胞类型之间的前馈和反馈通路的强度大致成比例。该模型与斯特尔模型形成鲜明对比，在斯特尔模型中，三种水平细胞类型的光谱行为由视锥细胞和水平细胞之间的前馈和反馈通路级联来解释。斯特尔模型解释了水平细胞的光谱行为，但没有解释其动态行为。
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