Glinski W, Glinska-Ferenz M, Pierozynska-Dubowska M
Department of Dermatology, Warsaw School of Medicine, Poland.
Acta Derm Venereol. 1991;71(1):51-4.
Increasing doses of capsaicin were applied topically to the forearm skin of 30 patients with psoriasis, 16 patients with systemic scleroderma and 16 healthy volunteers. Only one-third of the patients with psoriasis responded with neurogenic inflammation to capsaicin doses of 0.125 and 0.25 microgram/cm2 in contrast to 81% of scleroderma patients and all the normal controls, who showed a positive cutaneous reaction. Higher doses of capsaicin (0.5-4 micrograms/cm2) were required to induce erythema and flare in patients with late-onset psoriasis (after 21 years of age) as well as in patients with more than 40% of skin surface involved with psoriatic lesion.
将不同剂量的辣椒素局部应用于30例银屑病患者、16例系统性硬皮病患者和16名健康志愿者的前臂皮肤。只有三分之一的银屑病患者对0.125和0.25微克/平方厘米剂量的辣椒素产生神经源性炎症反应，相比之下，81%的硬皮病患者和所有正常对照者均表现出阳性皮肤反应。对于晚发型银屑病（21岁以后发病）患者以及银屑病皮损累及皮肤表面超过40%的患者，需要更高剂量的辣椒素（0.5 - 4微克/平方厘米）才能诱发红斑和潮红。
