Glinski W, Brodecka H, Glinska-Ferenz M, Kowalski D
Department of Dermatology, Warsaw School of Medicine, Poland.
Int J Dermatol. 1994 May;33(5):356-60. doi: 10.1111/j.1365-4362.1994.tb01068.x.
An increased concentration of neuropeptides in psoriatic lesional skin may be responsible for alterations in the neurogenic erythematous response and transmission of stimuli through sensory nerve fibers (sensation of pruritus).
Increasing doses of capsaicin from 0.125 to 4 micrograms/cm2 were applied to nonlesional psoriatic skin to establish the minimal dose that induced the substance P-mediated neurogenic response in 30 patients with psoriasis. Plasma beta-endorphin was quantitated in 71 psoriatics by radioimmunoassay using NEN 1251-RIA kit.
The mean beta-endorphin concentration was increased about 2-fold compared to normals, whereas doses of capsaicin needed to induce erythema were higher (1-4 micrograms/cm2) in psoriatics (mainly in patients with type II psoriasis) than in healthy subjects (0.125-0.25 microgram/cm2).
The data indicate that increased beta-endorphin in psoriatic skin might affect both substance P-mediated neurogenic inflammation and transmission of sensory stimuli due to local antinociceptive effects of this opioid. The differences in the neurogenic response in type I and II psoriasis may be related to the degradation of substance P and beta-endorphin by neutral proteinases in the lesional skin.
银屑病皮损皮肤中神经肽浓度的增加可能是导致神经源性红斑反应改变以及刺激通过感觉神经纤维传递（瘙痒感）的原因。
将辣椒素剂量从0.125微克/平方厘米增加至4微克/平方厘米，涂抹于银屑病非皮损皮肤，以确定在30例银屑病患者中诱导P物质介导的神经源性反应所需的最小剂量。使用NEN 125I-RIA试剂盒通过放射免疫分析法对71例银屑病患者的血浆β-内啡肽进行定量分析。
与正常人相比，β-内啡肽平均浓度增加了约2倍，而银屑病患者（主要是II型银屑病患者）诱导红斑所需的辣椒素剂量（1-4微克/平方厘米）高于健康受试者（0.125-0.25微克/平方厘米）。
数据表明，银屑病皮肤中β-内啡肽增加可能会因这种阿片类物质的局部抗伤害感受作用而影响P物质介导的神经源性炎症和感觉刺激的传递。I型和II型银屑病神经源性反应的差异可能与皮损皮肤中中性蛋白酶对P物质和β-内啡肽的降解有关。
