Arakawa Soichi, Nakano Yuzo, Miura Tetsuya, Shigemura Katsumi, Tanaka Kazushi, Fujisawa Masato
Division of Urology, Department of Organs Therapeutics, Faculty of Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
Int J Urol. 2006 Dec;13(12):1484-7. doi: 10.1111/j.1442-2042.2006.01657.x.
To evaluate the influences the change of the measurement method of pyuria from conventional centrifuged sediment to microchamber uncentrifuged urine for the results of evaluation of antimicrobial agents in clinical study against complicated urinary tract infections. From the viewpoint of international harmonization of judgement criteria, the recent method for counting white blood cells (WBC) in urine has changed from using uncentrifuged urine to using a microchamber in all countries.
Targeted diseases were non-catheterized complicated urinary tract infection, and cefcapene pivoxil hydrochloride or levofloxacin were used as antimicrobial drug. Pyuria was examined using the counting chamber method, a quantitative method using uncentrifuged urine with a microchamber, and the sedimentation method.
Overall clinical efficacy in early evaluation by the two methods in measuring pyuria was evaluated as different in eight patients (7.3%). It was rated excellent in 63 (52.9%), moderate in 32 patients (26.9%) and poor in 24 (20.2%) with an efficacy rate of 79.8% using the counting chamber method, and excellent in 68 (57.1%), moderate in 27 (22.7%) and poor in 24 (20.2%) with an efficacy rate of 79.8% using the conventional sedimentation method
No significant difference was seen between the two methods of WBC count in urine.
评估在针对复杂性尿路感染的临床研究中，脓尿测量方法从传统离心沉淀法改为微室未离心尿液法对抗菌药物评估结果的影响。从判断标准国际协调的角度来看，目前所有国家尿液中白细胞（WBC）计数方法已从使用未离心尿液改为使用微室法。
目标疾病为非导尿性复杂性尿路感染，使用盐酸头孢卡品酯或左氧氟沙星作为抗菌药物。采用计数室法、使用微室对未离心尿液进行定量的方法以及沉淀法检测脓尿。
两种测量脓尿方法早期评估的总体临床疗效在8例患者（7.3%）中被评估为不同。使用计数室法时，63例（52.9%）疗效评为优，32例（26.9%）为中，24例（20.2%）为差；有效率为79.8%。使用传统沉淀法时，68例（57.1%）疗效评为优，27例（22.7%）为中，24例（20.2%）为差；有效率为79.8%。
两种尿液白细胞计数方法之间未见显著差异。
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