Geijer Roeland M M, Sachs Alfred P E, Verheij Theo J M, Lammers Jan-Willem J, Salomé Philippe L, Hoes Arno W
Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, The Netherlands.
Scand J Prim Health Care. 2006 Dec;24(4):237-42. doi: 10.1080/02813430601016894.
To determine whether in a high-risk group of middle-aged male current smokers, patient characteristics are useful to recognize mild COPD (GOLD stage I).
In a cross-sectional study spirometry was performed according to the American Thoracic Society criteria. COPD was defined according to the GOLD criteria for COPD.
Primary care.
Male smokers, aged 40-65 years, without documented lung disease in the population at large.
Medical records were scrutinized to collect patient characteristics. Multiple logistic regression analysis was used to identify independent determinants of mild COPD.
A total of 567 subjects participated. COPD, defined by a FEV1/FVC ratio < 0.7, was detected in 170 subjects (30.0%, 95% CI 26.2-33.9%). In 149 subjects (26.3%; 22.7-30.1%) COPD was mild (GOLD stage I) and in 21 subjects (3.7%; 2.3-5.6%) moderate (GOLD stage II). Only age and cough were independently associated with the presence of mild COPD. The ability of these determinants to discriminate between subjects with or without mild COPD was relatively poor (ROC area 0.65). Therefore no prediction rule was developed.
Our results indicate that patient characteristics are not helpful to recognize mild COPD (GOLD stage I) in middle-aged male smokers.
确定在中年男性现吸烟者这一高危群体中，患者特征是否有助于识别轻度慢性阻塞性肺疾病（GOLD 1期）。
在一项横断面研究中，根据美国胸科学会标准进行肺功能测定。慢性阻塞性肺疾病根据慢性阻塞性肺疾病的GOLD标准进行定义。
初级保健机构。
年龄在40 - 65岁的男性吸烟者，总体人群中无肺部疾病记录。
仔细审查病历以收集患者特征。采用多元逻辑回归分析来确定轻度慢性阻塞性肺疾病的独立决定因素。
共有567名受试者参与。在170名受试者（30.0%，95%可信区间26.2 - 33.9%）中检测到慢性阻塞性肺疾病，定义为FEV1/FVC比值<0.7。149名受试者（26.3%；22.7 - 30.1%）为轻度慢性阻塞性肺疾病（GOLD 1期），21名受试者（3.7%；2.3 - 5.6%）为中度（GOLD 2期）。只有年龄和咳嗽与轻度慢性阻塞性肺疾病的存在独立相关。这些决定因素区分有或无轻度慢性阻塞性肺疾病受试者的能力相对较差（ROC曲线下面积为0.65）。因此未制定预测规则。
我们的结果表明，患者特征无助于识别中年男性吸烟者中的轻度慢性阻塞性肺疾病（GOLD 1期）。
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