甲硫氨酸合酶基因多态性c.2756A>G改变了多形性胶质母细胞瘤的易感性。
The methionine synthase polymorphism c.2756A>G alters susceptibility to glioblastoma multiforme.
作者信息
Semmler Alexander, Simon Matthias, Moskau Susanna, Linnebank Michael
机构信息
Department of Neurology, University Hospital Bonn, Sigmund-Freud-Strasse, 25, 53105 Bonn, Germany.
出版信息
Cancer Epidemiol Biomarkers Prev. 2006 Nov;15(11):2314-6. doi: 10.1158/1055-9965.EPI-05-0979.
Genetic polymorphisms of methionine metabolism, in particular methionine synthase (MTR) c.2756A>G (D919G) and methylenetetrahydrofolate reductase (MTHFR) c.677C>T (A222V), have been associated with various human cancers. We investigated MTR c.2756A>G, MTHFR c.677C>T, and a third polymorphism, transcobalamin 2 c.776C>G (P259R), for a potential association with the formation of glioblastoma multiforme. The MTR c.2756G allele was significantly underrepresented among 328 glioblastoma multiforme patients of Caucasian origin when compared with 400 population controls [patients AA/AG/GG: 0.72/0.26/0.02 and controls AA/AG/GG: 0.57/0.38/0.05, degrees of freedom = 2; chi(2) = 17.86 (Pearson); P < 0.001]. No association between glioblastoma multiforme and the two other polymorphisms was observed.
甲硫氨酸代谢的基因多态性，特别是甲硫氨酸合成酶（MTR）c.2756A>G（D919G）和亚甲基四氢叶酸还原酶（MTHFR）c.677C>T（A222V），已与多种人类癌症相关。我们研究了MTR c.2756A>G、MTHFR c.677C>T以及第三种多态性，即转钴胺素2 c.776C>G（P259R），以探讨其与多形性胶质母细胞瘤形成的潜在关联。与400名人群对照相比，在328名高加索裔多形性胶质母细胞瘤患者中，MTR c.2756G等位基因的比例显著偏低[患者AA/AG/GG：0.72/0.26/0.02，对照AA/AG/GG：0.57/0.38/0.05，自由度 = 2；卡方 = 17.86（皮尔逊）；P < 0.001]。未观察到多形性胶质母细胞瘤与其他两种多态性之间存在关联。
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