Wagenknecht Hans-Achim
University of Regensburg, Institute for Organic Chemistry, D-93040, Regensburg, Germany.
Nat Prod Rep. 2006 Dec;23(6):973-1006. doi: 10.1039/b504754b. Epub 2006 Aug 30.
In principle, DNA-mediated charge transfer processes can be categorized as oxidative hole transfer and reductive electron transfer. With respect to the routes of DNA damage most of the past research has been focused on the investigation of oxidative hole transfer or transport. On the other hand, the transport or transfer of excess electrons has a large potential for biomedical applications, mainly for DNA chip technology.
原则上,DNA介导的电荷转移过程可分为氧化空穴转移和还原电子转移。就DNA损伤途径而言,过去的大多数研究都集中在氧化空穴转移或传输的研究上。另一方面,多余电子的传输或转移在生物医学应用中具有很大潜力,主要用于DNA芯片技术。