van Gelder Rogier E, Florie Jasper, Nio C Yung, Jensch Sebastiaan, de Jager Steven W, Vos Frans M, Venema Henk W, Bartelsman Joep F, Reitsma Johannes B, Bossuyt Patrick M M, Laméris Johan S, Stoker Jaap
Department of Radiology, Academic Medical Center of the University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.
Eur Radiol. 2007 May;17(5):1181-92. doi: 10.1007/s00330-006-0487-8. Epub 2006 Nov 22.
The aim of our study was to compare primary three-dimensional (3D) and primary two-dimensional (2D) review methods for CT colonography with regard to polyp detection and perceptive errors. CT colonography studies of 77 patients were read twice by three reviewers, first with a primary 3D method and then with a primary 2D method. Mean numbers of true and false positives, patient sensitivity and specificity and perceptive errors were calculated with colonoscopy as a reference standard. A perceptive error was made if a polyp was not detected by all reviewers. Mean sensitivity for large (> or = 10 mm) polyps for primary 3D and 2D review was 81% (14.7/18) and 70%(12.7/18), respectively (p-values > or = 0.25). Mean numbers of large false positives for primary 3D and 2D were 8.3 and 5.3, respectively. With primary 3D and 2D review 1 and 6 perceptive errors, respectively, were made in 18 large polyps (p = 0.06). For medium-sized (6-9 mm) polyps these values were for primary 3D and 2D, respectively: mean sensitivity: 67%(11.3/17) and 61%(10.3/17; p-values > or = 0.45), number of false positives: 33.3 and 15.6, and perceptive errors : 4 and 6 (p = 0.53). No significant differences were found in the detection of large and medium-sized polyps between primary 3D and 2D review.
我们研究的目的是比较CT结肠成像的原始三维（3D）和原始二维（2D）检查方法在息肉检测及认知错误方面的差异。77例患者的CT结肠成像研究由三名阅片者进行两次阅片，首先采用原始3D方法，然后采用原始2D方法。以结肠镜检查作为参考标准，计算真阳性和假阳性的平均数量、患者的敏感度和特异度以及认知错误。如果所有阅片者均未检测到息肉，则判定为发生认知错误。原始3D和2D检查对大息肉（≥10 mm）的平均敏感度分别为81%（14.7/18）和70%（12.7/18）（p值≥0.25）。原始3D和2D检查大息肉的平均假阳性数量分别为8.3和5.3。对于18个大息肉，原始3D和2D检查分别出现1例和6例认知错误（p = 0.06）。对于中等大小（6 - 9 mm）的息肉，原始3D和2D检查的相应值分别为：平均敏感度：67%（11.3/17）和61%（10.3/17；p值≥0.45），假阳性数量：33.3和15.6，以及认知错误：4例和6例（p = 0.53）。原始3D和2D检查在大息肉和中等大小息肉的检测方面未发现显著差异。
