Kovacević Dujo, Sonicki Zdenko, Kusić Zvonko, Bolanca Ante, Grubisić Goran, Lukac Maja, Lukac Josip
Department of Surgery, Sisters of Charity University Hospital, Vinogradska 29, 10000, Zagreb, Croatia.
Int J Colorectal Dis. 2007 Jul;22(7):827-31. doi: 10.1007/s00384-006-0200-z. Epub 2006 Nov 22.
Soluble c-erbB-2 oncoprotein has been proven as a useful marker in the management of breast cancer patients, but its value in diagnostics and follow-up of colorectal cancer patients remains controversial. The aim of this study was to evaluate the usefulness of serum c-erbB-2 monitoring in diagnostics and prediction of disease outcome in rectal cancer patients.
Serum samples from 88 patients with rectal adenocarcinoma before surgery and from 41 healthy controls were tested for the presence of c-erbB-2 oncoprotein by ELISA, and the patients were followed up for at least 5 years after the surgery.
Preoperative serum c-erbB-2 levels were significantly higher in stage IV patients than in healthy controls (P<0.001) and did not show correlation with preoperative CEA levels. Elevated preoperative serum c-erbB-2 levels showed relatively high specificity (88%) and low sensitivity (44%) in the diagnosis of rectal cancer. Elevated preoperative oncoprotein levels were predictive neither for overall survival nor for development of local recurrence/distant metastases.
Although preoperative serum c-erbB-2 levels were significantly higher in rectal cancer patients than in healthy controls, the soluble c-erbB-2 does not seem to be useful in the diagnosis of rectal cancer due to its low sensitivity. Preoperative serum levels of this oncoprotein were predictive neither for overall survival nor for local recurrence/distant metastases in rectal cancer patients.
可溶性c-erbB-2癌蛋白已被证明是乳腺癌患者管理中的一个有用标志物，但其在结直肠癌患者诊断和随访中的价值仍存在争议。本研究的目的是评估血清c-erbB-2监测在直肠癌患者诊断和疾病预后预测中的作用。
采用酶联免疫吸附测定法（ELISA）检测88例直肠腺癌患者术前血清样本及41例健康对照者血清中c-erbB-2癌蛋白的存在情况，并对患者术后至少随访5年。
IV期患者术前血清c-erbB-2水平显著高于健康对照者（P<0.001），且与术前癌胚抗原（CEA）水平无相关性。术前血清c-erbB-2水平升高在直肠癌诊断中显示出相对较高的特异性（88%）和较低的敏感性（44%）。术前癌蛋白水平升高对总生存期及局部复发/远处转移的发生均无预测价值。
尽管直肠癌患者术前血清c-erbB-2水平显著高于健康对照者，但由于其敏感性较低，可溶性c-erbB-2在直肠癌诊断中似乎并无用处。该癌蛋白术前血清水平对直肠癌患者的总生存期及局部复发/远处转移均无预测价值。
