Nilsson Kent W, Damberg Mattias, Ohrvik John, Leppert Jerzy, Lindström Leif, Anckarsäter Henrik, Oreland Lars
Centre for Clinical Research, Uppsala University, Central Hospital Västerås (1), SE-721 89 Västerås, Sweden.
Neurosci Lett. 2007 Jan 16;411(3):233-7. doi: 10.1016/j.neulet.2006.10.051. Epub 2006 Nov 22.
In several twin studies the relative contribution of genetic factors for personality traits has amounted to figures between 40 and 60%. In the present study we investigated to which degree polymorphisms in the 5-HTT and AP-2beta genes are implicated in the neural processes involved in the formation of Temperament and Character traits, as estimated by Cloninger's TCI. Considering the background of previous reports, associations with the character Self-Transcendence and its sub-scale Spiritual Acceptance in particular, were of interest. A stratified random sample of 200 individuals (total population=5173), matched for age, gender and risk behaviors, from volunteering 16- and 19-year-old adolescents students in Sweden was investigated. Cloninger's TCI inventory was used for investigation of temperament and character traits. Blood samples were used for analyses of a promoter serotonin transporter polymorphism (5-HTTLPR) and an intron 2 polymorphism in the transcription factor AP-2beta gene. Among boys individuals with presence of the short 5-HTTLPR genotype showed lower scores, whereas individuals with presence of the short AP-2beta genotype showed higher scores of personality character Self-Transcendence and its sub-scale Spiritual Acceptance. Among girls no effect of either genotype was found. Both among boys and girls, significant interactive effects were found between 5-HTTLPR and AP-2beta genotypes, with regard to Self-Transcendence and Spiritual acceptance. Boys and girls with the combination of presence of the short 5-HTTLPR, and homozygosity for the long AP-2beta genotype scored significantly lower on Self-Transcendence and Spiritual Acceptance.
在多项双胞胎研究中，遗传因素对人格特质的相对贡献达到了40%至60%。在本研究中，我们调查了5-HTT和AP-2β基因的多态性在多大程度上与由克隆宁格的气质性格量表（TCI）所估计的气质和性格特质形成过程中的神经过程有关。考虑到先前报告的背景，特别关注与性格自我超越及其子量表精神接受性的关联。我们对来自瑞典16岁和19岁自愿参与的青少年学生的200名个体（总人口=5173）进行了分层随机抽样，这些个体在年龄、性别和风险行为方面进行了匹配。使用克隆宁格的TCI量表来调查气质和性格特质。采集血样用于分析启动子血清素转运体多态性（5-HTTLPR）和转录因子AP-2β基因的内含子2多态性。在男孩中，存在短5-HTTLPR基因型的个体得分较低，而存在短AP-2β基因型的个体在人格特质自我超越及其子量表精神接受性方面得分较高。在女孩中，未发现任何一种基因型有影响。在男孩和女孩中，就自我超越和精神接受性而言，均发现5-HTTLPR和AP-2β基因型之间存在显著的交互作用。具有短5-HTTLPR基因型且AP-2β基因组长纯合子组合的男孩和女孩在自我超越和精神接受性方面得分显著较低。
