低频重复经颅磁刺激对大鼠脑电图的影响。
The influence of low-frequency rTMS on EEG of rats.
作者信息
Li Linxia, Yin Zhenggang, Huo Xiaolin
机构信息
Bioelectromagnetic Lab, Institute of Electrical Engineering, Chinese Academy of Sciences, Beijing 100080, China.
出版信息
Neurosci Lett. 2007 Jan 29;412(2):143-7. doi: 10.1016/j.neulet.2006.10.054. Epub 2006 Nov 22.
This study aimed to determine the effect of low-frequency repetitive transcranial magnetic stimulation (rTMS) on electroencephalograms (EEGs) of rats. Fifteen Sprague-Dawley rats were subject to 100 pulses of 0.5 Hz rTMS, or sham stimulation. EEGs were recorded before stimulation and within 1 min after rTMS or sham stimulation. Estimates of the EEG correlation dimension (D(2)) and power spectra were calculated. Results show that the D(2) reduced significantly after low-frequency rTMS, but not after sham stimulation. Mean absolute power (MAP) of the gamma band and relative power (RP) of the beta and gamma bands reduce markedly after low-frequency rTMS, but there are no changes with sham stimulation. These results indicate that low-frequency rTMS could affect cortical activities significantly, but effects were markedly different from those of high-frequency rTMS.
本研究旨在确定低频重复经颅磁刺激（rTMS）对大鼠脑电图（EEG）的影响。15只Sprague-Dawley大鼠接受了100次0.5Hz的rTMS脉冲刺激或假刺激。在刺激前以及rTMS或假刺激后1分钟内记录脑电图。计算脑电图关联维数（D(2)）和功率谱估计值。结果显示，低频rTMS后D(2)显著降低，但假刺激后未降低。低频rTMS后γ频段的平均绝对功率（MAP）以及β和γ频段的相对功率（RP）显著降低，但假刺激后无变化。这些结果表明，低频rTMS可显著影响皮层活动，但效应与高频rTMS明显不同。
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