低频重复经颅磁刺激可预防慢性癫痫发作。
Low-frequency repetitive transcranial magnetic simulation prevents chronic epileptic seizure.
机构信息
Department of Neurology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, Sichuan Province, China.
出版信息
Neural Regen Res. 2013 Sep 25;8(27):2566-72. doi: 10.3969/j.issn.1673-5374.2013.27.008.
Although low-frequency repetitive transcranial magnetic simulation can potentially treat epilepsy, its underlying mechanism remains unclear. This study investigated the influence of low-frequency re-petitive transcranial magnetic simulation on changes in several nonlinear dynamic electroence-phalographic parameters in rats with chronic epilepsy and explored the mechanism underlying petitive transcranial magnetic simulation-induced antiepileptic effects. An epilepsy model was es-tablished using lithium-pilocarpine intraperitoneal injection into adult Sprague-Dawley rats, which were then treated with repetitive transcranial magnetic simulation for 7 consecutive days. Nonlinear electroencephalographic parameters were obtained from the rats at 7, 14, and 28 days post-stimulation. Results showed significantly lower mean correlation-dimension and Kolmogo-rov-entropy values for stimulated rats than for non-stimulated rats. At 28 days, the complexity and point-wise correlation dimensional values were lower in stimulated rats. Low-frequency repetitive transcranial magnetic simulation has suppressive effects on electrical activity in epileptic rats, thus explaining its effectiveness in treating epilepsy.
尽管低频重复经颅磁刺激可能具有治疗癫痫的潜力，但它的潜在机制仍不清楚。本研究探讨了低频重复经颅磁刺激对慢性癫痫大鼠几种非线性动态脑电图参数变化的影响，并探索了重复经颅磁刺激诱导抗癫痫作用的机制。使用锂-匹罗卡品腹腔注射成年 Sprague-Dawley 大鼠建立癫痫模型，然后对其进行 7 天连续重复经颅磁刺激治疗。在刺激后 7、14 和 28 天，从大鼠中获得非线性脑电图参数。结果显示，刺激组大鼠的平均关联维数和 Kolmogorov 熵值明显低于非刺激组。在 28 天，刺激组大鼠的复杂性和逐点关联维数值较低。低频重复经颅磁刺激对癫痫大鼠的电活动具有抑制作用，这解释了其治疗癫痫的有效性。
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