Fornasari María Silvina, Parisi Gustavo, Echave Julián
Mol Biol Evol. 2007 Feb;24(2):349-51. doi: 10.1093/molbev/msl181. Epub 2006 Nov 23.
The structurally constrained protein evolution (SCPE) model simulates protein divergence considering protein structure explicitly. The model is based on the observation that protein structure is more conserved during evolution than the sequences encoding for that structure. In the previous work, the SCPE model considered only the tertiary structure. Here we show that the performance of the model is enhanced when the oligomeric structure is taken into account. Our results agree with recent evolutionary studies of oligomeric proteins, which show that conservation of the quaternary structure imposes additional constraints on sequence divergence. The incorporation of protein-protein interactions into protein evolution models may be important in the study of quaternary protein structures and complex protein assemblies.
结构受限蛋白质进化（SCPE）模型在明确考虑蛋白质结构的情况下模拟蛋白质的分化。该模型基于这样的观察结果：在进化过程中，蛋白质结构比编码该结构的序列更保守。在之前的工作中，SCPE模型仅考虑三级结构。在此我们表明，当考虑寡聚结构时，该模型的性能会得到提升。我们的结果与最近对寡聚蛋白的进化研究一致，这些研究表明四级结构的保守性对序列分化施加了额外的限制。将蛋白质 - 蛋白质相互作用纳入蛋白质进化模型可能在四级蛋白质结构和复杂蛋白质组装的研究中具有重要意义。
