Schubert P, Ferroni S, Mager R
Max-Planck-Institute for Psychiatry, Department of Neuromorphology, Martinsried, F.R.G.
Neurosci Lett. 1991 Apr 1;124(2):174-7. doi: 10.1016/0304-3940(91)90087-a.
Stimulus train-evoked decreases of the extracellular Ca2+ concentration (delta Ca) were measured with ion-sensitive electrodes in the CA1 area of rat hippocampal slices. The adenosine receptor antagonist, theophylline, led to a marked increase of delta Ca in the synaptic and in the soma layer reflecting an increased activation and enhanced frequency potentiation of pyramidal neurons in the absence of endogenous adenosine action. The theophylline effect was significantly reduced in the presence of the C1 channel blocker, 4,4'-diisothiocyano-2,2'-stilbenedisulfonate (DIDS) or of the Cl- pump blocker, furosemide. The data indicate that the adenosine-mediated modulation of the repetitive input strength is related to the function of Cl- ions.
用离子敏感电极在大鼠海马切片的CA1区测量刺激串诱发的细胞外Ca2+浓度降低（δCa）。腺苷受体拮抗剂茶碱导致突触层和胞体层的δCa显著增加，这反映了在没有内源性腺苷作用的情况下，锥体神经元的激活增加和频率增强。在存在Cl-通道阻滞剂4,4'-二异硫氰基-2,2'-二苯乙烯二磺酸盐（DIDS）或Cl-泵阻滞剂呋塞米的情况下，茶碱的作用显著降低。数据表明，腺苷介导的对重复输入强度的调节与Cl-离子的功能有关。
