Johnson Paul, Rosewell Mary, James Martin A
Department of Medicine for the Elderly, Royal Devon and Exeter Hospital, Exeter, UK.
Cerebrovasc Dis. 2007;23(2-3):156-61. doi: 10.1159/000097053. Epub 2006 Nov 16.
Patients remain at high risk of vascular events after stroke, transient ischaemic attack or carotid endarterectomy. We studied how well this risk is addressed by the effective treatment of modifiable risk factors.
A total of 198 consecutive attenders at a rapid access stroke clinic and 98 consecutive patients undergoing carotid endarterectomy were studied. Treatment of hypertension and hyperlipidaemia, smoking status and the use of antithrombotic therapy were assessed at baseline and 6 months later. The findings were compared with targets from the UK National Clinical Guidelines for Stroke.
Baseline and follow-up data were available on 284 patients. The rates of control of vascular risk factors improved only slightly during follow-up. Blood pressure was below target levels in only 69 (24%) at baseline and 79 (28%) at 6 months, and serum cholesterol was below target levels in only 55 (19%) at baseline and 63 (22%) at 6 months. At baseline, 55 (19%) were smokers, of whom 12 (22%) had quit at 6 months. Anticoagulant therapy was prescribed in 19 of 37 patients (51%) in atrial fibrillation at 6 months. Antiplatelet therapy was prescribed in 90% of patients in sinus rhythm.
Despite the identification of vascular risk factors at the time of clinic or surgery, 6 months later these risk factors remain poorly addressed. More effective methods of managing vascular risk in these patients are needed.
中风、短暂性脑缺血发作或颈动脉内膜切除术后患者仍有较高的血管事件风险。我们研究了通过有效治疗可改变的风险因素来降低这种风险的效果如何。
对一家快速通道中风诊所的198例连续就诊者和98例连续接受颈动脉内膜切除术的患者进行了研究。在基线和6个月后评估高血压和高脂血症的治疗情况、吸烟状况以及抗血栓治疗的使用情况。将研究结果与英国国家中风临床指南的目标进行比较。
284例患者有基线和随访数据。随访期间血管危险因素的控制率仅略有改善。基线时只有69例(24%)血压低于目标水平,6个月时为79例(28%);基线时只有55例(19%)血清胆固醇低于目标水平,6个月时为63例(22%)。基线时,55例(19%)为吸烟者,其中6个月时12例(22%)已戒烟。6个月时,37例房颤患者中有19例(51%)接受了抗凝治疗。窦性心律患者中90%接受了抗血小板治疗。
尽管在诊所就诊或手术时已识别出血管危险因素,但6个月后这些危险因素仍未得到有效控制。需要更有效的方法来管理这些患者的血管风险。