Yoshimura R, Ueda N, Shinkai K, Nakamura J
Pharmacopsychiatry. 2006 Nov;39(6):233-4. doi: 10.1055/s-2006-951386.
Two patients with bipolar I disorder were successfully treated with a combination of risperidone and lithium in their acute manic states and maintenance periods. Although lithium monotherapy alone could not prevent relapse in these patients, the addition of a low dose of risperidone was well tolerated and effective for preventing recurrence over the long term. Plasma levels of HVA and MHPG were found to be elevated during the manic episodes and gradually decreased after the risperidone treatment. These results indicate that a low dose of risperidone to the lithium regimen was an effective and well tolerated means for treatment in the acute manic state and the later maintenance period in parallel with decreasing plasma levels of HVA and MHPG.
两名双相I型障碍患者在急性躁狂发作期和维持期接受利培酮与锂盐联合治疗，取得了成功。尽管单独使用锂盐单药治疗无法预防这些患者复发，但加用低剂量利培酮耐受性良好，且能长期有效预防复发。在躁狂发作期间，发现血浆高香草酸（HVA）和3-甲氧基-4-羟基苯乙二醇（MHPG）水平升高，利培酮治疗后逐渐下降。这些结果表明，在锂盐治疗方案中加用低剂量利培酮，是在急性躁狂状态及后续维持期进行治疗的一种有效且耐受性良好的方法，同时还能降低血浆HVA和MHPG水平。
