Crucitti F, Doglietto G B, Costamagna G, Frontera D, Ferrante A M, Montemaggi P, Trodella L, Dobelbower R R
Istituto di Clinica Chirurgica, Cattedra di Patologia Chirurgica, Universitá Cattolica del Sacro Cuore, Rome, Italy.
J Surg Oncol. 1991 Jul;47(3):161-4. doi: 10.1002/jso.2930470305.
One hundred patients with pancreatic cancer were evaluated between March 1981 and December 1989. This study showed that 61 were not candidates for definitive surgery because of nonoperability (28 patients) or nonresectability (33 patients). An additional 25 patients had cancers that were unresectable because of metastases (13 patients) or local spread of disease (12 patients) discovered at laparotomy. Fourteen patients had resectable cancers. Ten were treated by total pancreatectomy, three by distal pancreatectomy and one by pancreatoduodenectomy (Whipple). There were two operative mortalities. The median patient survival time was 20.5 months. Two patients survived 5 years. Five patients are alive at 3, 14, 18, and 47 months. Palliative surgical procedures performed in 18 patients included 10 biliary bypasses, 9 gastrojejunostomies, and 6 T-tube placements. This was associated with an operative mortality rate of 11%. The median survival time was 5 months. Other palliative measures included endoscopic placement of biliary and pancreatic stents (47 patients, 2.7% mortality rate), endoluminal radiation therapy, interstitial radiation therapy and external beam radiation therapy. The median survival time of patients so treated was 4.5 months.
1981年3月至1989年12月期间，对100例胰腺癌患者进行了评估。该研究表明，61例患者因无法手术（28例）或无法切除（33例）而不适合进行根治性手术。另外25例患者的癌症因剖腹手术时发现转移（13例）或疾病局部扩散（12例）而无法切除。14例患者的癌症可切除。10例行全胰切除术，3例行胰体尾切除术，1例行胰十二指肠切除术（惠普尔手术）。有2例手术死亡。患者的中位生存时间为20.5个月。2例患者存活了5年。5例患者分别在3、14、18和47个月时仍存活。18例患者接受的姑息性手术包括10例胆肠吻合术、9例胃空肠吻合术和6例T管置入术。这与11%的手术死亡率相关。中位生存时间为5个月。其他姑息性措施包括内镜下放置胆管和胰管支架（47例患者，死亡率2.7%）、腔内放射治疗、组织间放射治疗和外照射放疗。接受此类治疗的患者的中位生存时间为4.5个月。
