α-肾上腺素能阻滞剂对大鼠脑内5-羟色胺和5-羟吲哚乙酸水平的影响。
The effect of alpha-adrenolytics on the levels of 5-hydroxytryptamine and 5-hydroxyindoleacetic acid in rat's brain.
作者信息
Zebrowska-Lupina I, Kleinrok Z
出版信息
Pol J Pharmacol Pharm. 1975 Oct;27(Suppl):241-5.
Alpha-Adrenolytics (ABA)-phenoxybenzamine, phentolamine and aceperone-increase 5-hydroxyindoleacetic (5-HIAA) acid content in rat's brain. At the same time, these compounds either increase or do not affect 5-hydroxytryptamine (5-HT) level. Moreover, they potentiate L-dopa and reserpine-induced increase in 5-HIAA level and antagonized clonidine-induced decrease in 5-HIAA content. The experiments with probenecid indicate that the observed increase in 5-HIAA does not result from the deficient elimination of the metabolite from brain. The increase in 5-HT turnover in brain, due to ABA, is suggested.
α-肾上腺素能阻滞剂（ABA）——酚苄明、酚妥拉明和阿塞哌隆——可增加大鼠脑内5-羟吲哚乙酸（5-HIAA）的含量。同时，这些化合物要么增加要么不影响5-羟色胺（5-HT）水平。此外，它们可增强左旋多巴和利血平诱导的5-HIAA水平升高，并拮抗可乐定诱导的5-HIAA含量降低。丙磺舒实验表明，观察到的5-HIAA增加并非源于脑内代谢产物清除不足。提示ABA可导致脑内5-HT周转增加。
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