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Effects of lindane on fluidity and lipid composition in rat renal cortex membranes.

作者信息

Pérez-Albarsanz M A, López-Aparicio P, Senar S, Recio M N

机构信息

Departamento de Bioquímica y Biología Molecular, Universidad de Alcalá, Alcalá de Henares-Madrid, Spain.

出版信息

Biochim Biophys Acta. 1991 Jul 22;1066(2):124-30. doi: 10.1016/0005-2736(91)90178-b.

DOI:10.1016/0005-2736(91)90178-b
PMID:1713062
Abstract

The influence of lindane upon dynamic properties of plasma membranes from rat renal cortex has been investigated using a fluorescence polarization technique. Preincubation with lindane increased membrane fluidity in a manner that is dose-dependent. This increase was higher in brush border membranes than in basolateral membranes. However, a significant decrease of the membrane fluidity was found in brush border membranes when rats were injected with lindane for 12 days. A possible solution to this difference could involve a resistance to membrane disordering by lindane through a regulatory mechanism that would balance the amount of cholesterol and phospholipid classes in the renal cortex membranes of lindane-injected rats.

摘要

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