Vergara Teresa, Cofré Pamela, Cifuentes Soledad, Pulgar Ursula, Puebla Claudio, Velasco Susana
Departamento de Gastroenterología, Hospital Naval Almirante Nef, Chile.
Rev Med Chil. 2006 Aug;134(8):960-4. doi: 10.4067/s0034-98872006000800003. Epub 2006 Nov 14.
The diagnosis of inflammatory bowel disease is supported by clinical findings and complementary tests. The presence of specific serological markers could be helpful in the characterization of this condition.
To assess the prevalence of ANCA and ASCA in a group of patients with ulcerative colitis (UC) and its association with clinical features.
Sixty four patients with UC in remission (age range 16-72 years, 33 males) were studied. In a venous blood sample ANCA were measured by indirect immunofluorescence and ASCA by enzyme immune assays for IgG and IgA.
Forty four percent of patients were positive for ANCA, 9% for ASCA and 6% for both markers. There was a significant correlation between the presence of ANCA and duration of the UC (<5 years 50%, 5-10 years 42.9%, 15 years 30%) and the number of crises (one crises 31%, 2-5 crises 51.9% and >5 crises 87.5). The proportion of colectomized patients with positive ANCA was higher (57.1%).
The prevalence of ANCA in the studied population is similar to the published data. The presence of ANCA was significantly higher in UC patients with shorter evolution, higher number of crises and in those with a history of colectomy. There was a low prevalence of ASCA positive patients.
炎症性肠病的诊断依靠临床症状及辅助检查。特定血清学标志物的存在有助于对该病进行特征描述。
评估一组溃疡性结肠炎（UC）患者中抗中性粒细胞胞浆抗体（ANCA）和抗酿酒酵母抗体（ASCA）的患病率及其与临床特征的关联。
研究了64例处于缓解期的UC患者（年龄范围16 - 72岁，男性33例）。采集静脉血样，采用间接免疫荧光法检测ANCA，采用酶免疫分析法检测IgG和IgA型ASCA。
44%的患者ANCA呈阳性, 9%的患者ASCA呈阳性，6%的患者两种标志物均呈阳性。ANCA的存在与UC的病程（<5年50%，5 - 10年42.9%，>15年30%）及发作次数（1次发作31%，2 - 5次发作51.9%，>5次发作87.5%）之间存在显著相关性。接受结肠切除术的患者中ANCA阳性的比例更高（57.1%）。
研究人群中ANCA的患病率与已发表数据相似。在病程较短、发作次数较多以及有结肠切除病史的UC患者中ANCA的存在明显更高。ASCA阳性患者的患病率较低。
