在转化的BALB/C 3T3小鼠成纤维细胞中，肉豆蔻酰化富含丙氨酸的C激酶底物表达降低。
Decreased expression of the myristoylated alanine-rich C kinase substrate in transformed BALB/C 3T3 mouse fibroblasts.
作者信息
Otsuka M, Yang H C
机构信息
Division of Medical Oncology, Harbor-UCLA Medical Center, Torrance 90509.
出版信息
Biochem Biophys Res Commun. 1991 Jul 31;178(2):494-500. doi: 10.1016/0006-291x(91)90134-s.
Expression of the myristoylated alanine-rich C kinase substrate was studied in the untransformed A31 and the transformed BPA31, DA31 and KA31 BALB/c 3T3 mouse fibroblast cell lines. The MARCKS transcript was markedly reduced in the three transformed cell lines. Southern analysis revealed similar gene copy number and no apparent DNA rearrangement. In the untransformed A31 cells, the MARCKS mRNA was constitutive in the cell cycle.
在未转化的A31以及转化的BPA31、DA31和KA31 BALB/c 3T3小鼠成纤维细胞系中研究了豆蔻酰化富含丙氨酸的C激酶底物的表达。在三种转化细胞系中，MARCKS转录物明显减少。Southern分析显示基因拷贝数相似且无明显的DNA重排。在未转化的A31细胞中，MARCKS mRNA在细胞周期中是组成性的。
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