Liu Dong-hong, Wang Yan, Liao Xin-xue, Xu Ming-guo, Wang Jie-mei, Yang Zhen, Chen Long, Lü Ming-de, Lu Kun, Tao Jun
Department of Ultrasound, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China.
Chin Med J (Engl). 2006 Nov 20;119(22):1866-70.
Pulse wave velocity and flow-mediated vasodilation (FMD) are widely used as noninvasive modalities for evaluating atherosclerosis. However, it is not known whether pulse wave velocity is related to FMD in patients with coronary artery disease (CAD). Therefore, the present study was designed to investigate the alteration in brachial-ankle pulse wave velocity (baPWV) and endothelial function in CAD patients.
Thirty-three patients with CAD and thirty control subjects were recruited for this study. baPWV was measured non-invasively using a VP 1000 automated PWV/ABI analyzer (PWV/ABI, Colin Co. Ltd., Komaki, Japan). Endothelial function as reflected by FMD in the brachial artery was assessed with a high-resolution ultrasound device.
baPWV was increased in CAD patients compared with control subjects [(1756.1 +/- 253.1) cm/s vs (1495.3 +/- 202.3) cm/s, P < 0.01]. FMD was significantly reduced in CAD patients compared with control subjects [(5.2 +/- 2.1)% vs (11.1 +/- 4.4)%, P < 0.01]. baPWV correlated with FMD (r = -0.68, P < 0.001). The endothelium-independent vasodilation induced by sublingual nitroglycerin in the brachial artery was similar in the CAD group compared with the control group.
CAD is associated with increased baPWV and endothelial dysfunction. Increased baPWV parallels diminished endothelial function. Our data therefore suggest that baPWV can be used as a noninvasive surrogate index in clinical evaluation of endothelial function.
脉搏波速度和血流介导的血管舒张功能（FMD）作为评估动脉粥样硬化的无创手段被广泛应用。然而，冠状动脉疾病（CAD）患者的脉搏波速度与FMD是否相关尚不清楚。因此，本研究旨在调查CAD患者肱踝脉搏波速度（baPWV）和内皮功能的变化。
本研究招募了33例CAD患者和30例对照者。使用VP 1000自动脉搏波速度/踝臂指数分析仪（PWV/ABI，日本小牧市柯林株式会社）无创测量baPWV。使用高分辨率超声设备评估肱动脉FMD所反映的内皮功能。
与对照者相比，CAD患者的baPWV升高[（1756.1±253.1）cm/s对（1495.3±202.3）cm/s，P<0.01]。与对照者相比，CAD患者的FMD显著降低[（5.2±2.1）%对（11.1±4.4）%，P<0.01]。baPWV与FMD相关（r=-0.68，P<0.001）。CAD组与对照组相比，舌下硝酸甘油诱导的肱动脉内皮依赖性血管舒张功能相似。
CAD与baPWV升高和内皮功能障碍相关。baPWV升高与内皮功能降低平行。因此，我们的数据表明baPWV可作为临床评估内皮功能的无创替代指标。
