Ozdemir Davut, Cesur Salih, Annakkaya Ali Nihat, Tarhan Gulnur, Hoca Nevin Taci, Sencan Irfan, Aslan Turan, Ceyhan Ismail, Balbay Oner, Guclu Ertugrul
Department of Clinical Microbiology and Infectious Diseases, Abant Izzet Baysal University Duzce Medical School, Duzce, Turkey.
Med Sci Monit. 2006 Dec;12(12):CR521-524. Epub 2006 Nov 23.
The aim of this study was to compare serum neopterin levels in patients with active pulmonary tuberculosis, healthy healthcare workers who had close contact with patients, and healthy volunteers. All of the healthy volunteers stated that they had not encountered possible risk factors for exposure to Mycobacterium tuberculosis infection.
MATERIAL/METHODS: Thirty-nine patients, 39 healthy healthcare workers, and a control group of 39 healthy volunteers who had no infection or other diseases were included in this study. Neopterin assay was performed in accordance with the manufacturer's instructions.
Serum neopterin levels were 18.6+/-14.2 nmol/l in patients, 9.8+/-2.9 nmol/l in healthy healthcare workers, and 3.4+/-5.2 nmol/l in healthy volunteers. Serum neopterin levels in each group were significantly different from each other (p<0.01).
Levels of neopterin in patients and healthy healthcare workers significantly differ from the levels in healthy controls. The higher serum neopterin levels in healthy healthcare workers may be attributed to latent Mycobacterium tuberculosis infection, but it does not seem to be used in the diagnosis of latent Mycobacterium tuberculosis infection alone. However, more experiences are needed.
本研究旨在比较活动性肺结核患者、与患者有密切接触的健康医护人员以及健康志愿者的血清新蝶呤水平。所有健康志愿者均表示未曾接触过可能感染结核分枝杆菌的危险因素。
材料/方法：本研究纳入了39例患者、39名健康医护人员以及39名无感染或其他疾病的健康志愿者作为对照组。新蝶呤检测按照制造商的说明进行。
患者血清新蝶呤水平为18.6±14.2 nmol/l，健康医护人员为9.8±2.9 nmol/l，健康志愿者为3.4±5.2 nmol/l。各组血清新蝶呤水平彼此之间存在显著差异（p<0.01）。
患者和健康医护人员的新蝶呤水平与健康对照组的水平存在显著差异。健康医护人员血清新蝶呤水平较高可能归因于潜伏性结核分枝杆菌感染，但它似乎不能单独用于潜伏性结核分枝杆菌感染的诊断。然而，还需要更多的经验。
Zotero 插件