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纹状体限制性腺苷A2受体（RDC8）由脑啡肽能神经元表达，而非P物质神经元：原位杂交组织化学研究。

Striatal restricted adenosine A2 receptor (RDC8) is expressed by enkephalin but not by substance P neurons: an in situ hybridization histochemistry study.

作者信息

Schiffmann S N, Jacobs O, Vanderhaeghen J J

机构信息

Erasme Hospital, Faculty of Medicine, Université Libre de Bruxelles, Belgium.

出版信息

J Neurochem. 1991 Sep;57(3):1062-7. doi: 10.1111/j.1471-4159.1991.tb08257.x.

DOI:10.1111/j.1471-4159.1991.tb08257.x
PMID:1713612
Abstract

RDC8 has been recently cloned and characterized as an adenosine A2 receptor. This receptor is expressed exclusively by medium-sized neurons of the striatum as demonstrated by in situ hybridization. We have now studied the relationship of this receptor with three major components of the rat caudate-putamen: enkephalin, substance P, and choline acetyltransferase. Our results demonstrate that the adenosine A2 receptor is expressed exclusively by the enkephalinergic striatal subpopulation but not by the substance P-containing or cholinergic neurons.

摘要

RDC8最近已被克隆并鉴定为一种腺苷A2受体。原位杂交显示，该受体仅由纹状体中型神经元表达。我们现在研究了该受体与大鼠尾状核-壳核三个主要成分的关系：脑啡肽、P物质和胆碱乙酰转移酶。我们的结果表明，腺苷A2受体仅由脑啡肽能纹状体亚群表达，而不由含P物质的神经元或胆碱能神经元表达。

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