Paton J C, Paton A W
School of Molecular and Biomedical Science, University of Adelaide, Adelaide, Australia.
Kidney Int. 2006 Dec;70(12):2049-51. doi: 10.1038/sj.ki.5001954.
The pathway and the efficiency of intracellular trafficking of Shiga toxin differ between cell types, and this impacts on susceptibility to cytotoxicity. Warnier et al. demonstrate that in cell types targeted during human disease, Shiga toxin undergoes retrograde transport via the trans-Golgi network to the endoplasmic reticulum, albeit less efficiently than in HeLa cells.
志贺毒素在细胞内运输的途径和效率因细胞类型而异，这会影响细胞对细胞毒性的易感性。瓦尔尼尔等人证明，在人类疾病的靶向细胞类型中，志贺毒素通过反式高尔基体网络进行逆行转运至内质网，尽管其效率低于在HeLa细胞中的效率。
