Ozdemir M, Balevi S, Deniz F, Mevlitoğlu I
Department of Dermatology, Meram School of Medicine, Selçuk University, 42080 Konya, Turkey.
Clin Exp Dermatol. 2007 Jan;32(1):85-7. doi: 10.1111/j.1365-2230.2006.02284.x. Epub 2006 Nov 27.
Behçet's disease (BD) is a chronic inflammatory multisystemic disorder characterized mainly by vasculitis. Although the pathergy reaction (PR) has been accepted as one of the major criteria in this disease, there is a lack of a standardized method to measure PR. The aim of this study was to evaluate results of PR in different body areas and the effect on the positive rate of PR of application of numerous needle pricks. The pathergy test was performed using simultaneous 16 needle pricks with 20G disposable needles on different body areas of 56 patients with BD, 49 patients with recurrent aphthous stomatitis (RAS) and 17 healthy subjects. No positive PR was found in healthy controls, but was observed in nine patients with RAS (18.3%). It was detected in 48 of 56 patients with BD, a positive rate of 85.7%. The site most frequently positive for PR was the forearm, while the least frequent was the abdomen. Multiple needle pricks could play an important role in increasing the positive rate of PR in BD, and it may be important in the investigation of aetiological factors in RAS.
白塞病（BD）是一种主要以血管炎为特征的慢性炎症性多系统疾病。尽管同形反应（PR）已被公认为该病的主要标准之一，但缺乏一种标准化的方法来测量PR。本研究的目的是评估不同身体部位PR的结果以及多次针刺对PR阳性率的影响。使用20G一次性针头在56例BD患者、49例复发性阿弗他口炎（RAS）患者和17名健康受试者的不同身体部位同时进行16针针刺来进行同形反应试验。健康对照中未发现PR阳性，但在9例RAS患者中观察到PR阳性（18.3%）。56例BD患者中有48例检测到PR阳性，阳性率为85.7%。PR最常出现阳性的部位是前臂，而最少出现阳性的部位是腹部。多次针刺可能在提高BD患者PR阳性率方面发挥重要作用，并且在RAS病因学因素的研究中可能也很重要。
