Hochhaus A, Mindner K, Ostermann G, Höche D
Poliklinik für Innere Medizin, Medizinischen Akademie Erfurt.
Folia Haematol Int Mag Klin Morphol Blutforsch. 1990;117(6):765-70.
Patients with thrombocythaemia due to myeloproliferative disorders (n = 21), with secondary thrombocytosis of various origin (n = 16), and a control group of healthy donors (n = 20) were investigated with respect to the aggregation behaviour and the total calcium content of blood platelets. The calcium content was significantly lower in both groups of patients as compared to controls (2 p less than 0.001). In 16 of 21 patients with myeloproliferative disorders platelet rich plasma did not respond to epinephrine (15 mumol/l), a concentration which induced at least weak aggregation in 14 of 16 patients with secondary thrombocytosis and also in healthy subjects. In patients with thrombocythaemia the mean extent of aggregation induced by epinephrine, collagen or adenosin diphosphate was significantly lower as compared to controls (2 p less than 0.001).
对患有骨髓增殖性疾病导致的血小板增多症的患者（n = 21）、各种原因引起的继发性血小板增多症患者（n = 16）以及健康供体对照组（n = 20），就血小板的聚集行为和总钙含量进行了研究。与对照组相比，两组患者的钙含量均显著降低（P < 0.001）。在21例骨髓增殖性疾病患者中，有16例富含血小板血浆对肾上腺素（15 μmol/l）无反应，该浓度可诱导16例继发性血小板增多症患者中的14例以及健康受试者至少出现微弱聚集。与对照组相比，血小板增多症患者中由肾上腺素、胶原或二磷酸腺苷诱导的平均聚集程度显著降低（P < 0.001）。
